In this work twenty cases of keratocystic odontogenic tumor were stained by perlecan, syndecan1 cd8 and ki67 to study the biological behavior of the tumor. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Dental tumors stateautocollapse shows the template collapsed to the title bar if there is a navbar, a sidebar, or some other table on the page with the collapsible attribute. Odontogenic keratocyst okc is an aggressive, cystic jaw lesion with strong growth potential and a high recurrence rate. Total rna from 27 fresh tumor samples of 15 solidmulticystic intraosseous ameloblastomas and 12 sporadic kcots was hybridized on affymetrix whole genome arrays.
Expression of perlecan, syndecan1 and ki67 in keratocystic. The keratocystic odontogenic tumor kcot is a benign but aggressive lesion with high recurrent rate. Keratocystic odontogenic tumor may occur in any part of the jaws with a considerable predilection for the posterior body of the mandible and ascending ramus 10,14,16,20. The term keratocyst odontogenic was first introduced in 1956 by philipsen. Downloaded free from on wednesday, september 28, 2016. Histologically, odontogenic keratocysts are characterized by the presence of an external connective tissue capsule, with. Longitudinal image analysis of tumor size via 3d visualized ct scans. Dental tumors stateexpanded to show the template expanded, i. The odontogenic keratocyst okc may occur at any age. Cd166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma. There are many types of cysts of the jaws, but what makes the odontogenic keratocyst unusual are its characteristic histopathological and clinical features, including potentially aggressive behaviour, high recurrence rate, and an association with the nevoid basal cell carcinoma syndrome. Aug 11, 2009 the odontogenic keratocyst is a very well known odontogenic cyst. Identification of the involvement of loxl4 in generation of.
Keratocystic odontic tumors odontogenic keratocysts usually present in younger patients 2 nd3 rd decades and may be present in either the body or ramus of the mandible. Dental tumors statecollapsed to show the template collapsed, i. Odontogenic keratocysts okcs now reclassified as keratocystic odontogenic tumours kcots are a clinical entity with a characteristic microscopic picture, kinetic growth and biological behaviour. Immunohistochemical detection of laminin1 and ki67 in. The keratocystic odontogenic tumor oral and maxillofacial. Prognostic factors for keratocystic odontogenic tumor odontogenic keratocyst. In other words, odontogenic tumors arise from odontogenic tissues. Keratocystic odontogenic tumor kcot, previously known as odontogenic keratocyst okc, is a relatively common developmental odontogenic cyst that arises from the dental lamina remnants 6. Keratocystic odontogenic tumor kcot in the jaws arise from the cell rests of dental lamina and are usually seen during the second to fourth decades of life with a slight male. Show full abstract the world health organization 2005, the term keratocystic odontogenic tumor kcot was adopted for pokcs.
Conservative management of odontogenic keratocyst with longterm. The clinical features associated with the keratocystic odontogenic tumor show it to be a unilocular or multilocular radiolucency, occurring most frequently i. Odontogenic keratocyst okc is a benign lesion recently considered an. In 2005, the who working group considered odontogenic keratocyst okc to be a tumor and recommended the term keratocystic odontogenic tumor kcot, separating the lesion from the orthokeratinizing variant, which is now considered an odontogenic cyst. With the reclassification of keratocystic odontogenic tumor in 2005 as an odontogenic tumor, there were 8129 odontogenic tumors reported with 3001 36. Accordingly, we wanted to determine how podoplanin. Kots have been reclassified as neoplasms by the world health organization, and the term keratocystic odontogenic tumor has replaced the term odontogenic keratocysts. Clinical manifestations and treatment for keratocystic. An important aspect of the okc that should be underlined is that it can represent one component of the nevoid basal cell carcinoma syndrome nbcs 7. All the singular characteristics of this pathology have originated controversy in the scienti.
Diffusionweighted mr imaging of ameloblastomas and. Typically expansile, cortical thinning and breech is common. Apr, 2016 odontogenic keratocyst or keratocystic odontogengic tumor. Patients with larger lesions may present with pain secondary to infection of the cystic cavity. In this retrospective study, we examined 186 kcots treated at the. Keratocystic odontogenic tumor may occur in any part of the jaws with a considerable predilection for the posterior body of. Radiotherapy was not given to this current case because she was tumor free and adequate resection margins were confirmed in the excision. Topical 5fluorouracil is a novel targeted therapy for the. Keratocystic odontogenic tumor with an ectopic tooth in.
Immunohistochemical expression of protein 53, murine double. In recent years, the world health organization who revised its name to keratocystic odontogenic tumor kcot. Figure 2 depicts the percentage of patients who re mained free of recurrent kcots after the initial interven. A reconstruction of the 60 patients local oral mucosa was also performed with skin graft. Keratocystic odontogenic tumors kcot are benign, locally aggressive intraosseous tumors of odontogenic origin.
Winner of the standing ovation award for best powerpoint templates from presentations magazine. Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with carnoys solution int j oral maxillofac surg. In 1992 it was called a primordial cyst or odontogenic keratocyst. Keratocystic odontogenic tumour canadian dental association. According to who classification, kcot is defined as a benign neoplasm of odontogenic origin. Podoplanin expression profiles characteristic of odontogenic. Pdf keratocystic odontogenic tumor kcot has been identified as a. Keratocystic odontogenic tumors kcots are certainly among the most studied lesions in oral pathology, which is. Compared to other odontogenic cysts, this type occurs with a frequency of 515%. This study involved a pooled analysis of japanese individuals with nbccs and was performed with the aim of analyzing the clinical features of nbccs and the patterns of occurrence and recurrence of kcots in japanese individuals. Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial.
Keratocystic odontogenic tumors clinical and molecular features. It most often affects the posterior mandible and most commonly presents in the third decade of life. The keratocystic odontogenic tumour kcot is a benign intraosseous odontogenic lesion relatively frequent in the oral cavity. Overall, the recurrence rate was approximately 29%. Treatment options for keratocyst odontogenic tumour kcot.
Pdf keratocystic odontogenic tumor is considered to be a benign cystic. The discovery of increased mitotic activity in the cyst epithelium, the potential for epithelial budding from basal layer or daughter cysts in the cyst. Histological findings were epithelioid hemangioendothelioma with indications for radical resection of both the bone affected o. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Molecular analysis of keratocystic odontogenic tumor cell.
The odontogenic keratocyst okc is the most likely cyst to recur after treatment. Marx, in current therapy in oral and maxillofacial surgery, 2012 odontogenic keratocyst. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. Keratocystic odontogenic tumor with an ectopic tooth in maxilla. It has a locally aggressive behaviour and exhibits a high propensity to recur after treatment. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Histopathological features of keratocystic odontogenic tumor. Squamous cell carcinoma arising from a keratocystic odontogenic. Pdf keratocystic odontogenic tumor of mandible researchgate. Ppt odontogenic keratocyst powerpoint presentation. Investigations continue into the lesions pathologic classification, diagnosis and. Ameloblastoma, a type of odontogenic tumor involving ameloblasts.
The peak incidence is seen between 11 and 40 years of age. Most kcots arise in the mandible, and kcot is identified according to a characteristic. Matrix metalloproteinase expression in keratocystic. Keratocystic odontogenic tumors kcots are locally invasive, rapidly proliferating cystic lesions of the jaw. In 2005, the world health organization renamed the lesion previously known as an odontogenic keratocyst as the keratocystic odontogenic tumor. Kuroyanagi n1, sakuma h, miyabe s, machida j, kaetsu a, yokoi m, maeda h, warnakulasuriya s, nagao t, shimozato k. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. A left transcervical segmental mandibulectomy through an apron incision followed by mandibular reconstruction with left fibula free flap was. Conservative management of keratocystic odontogenic tumors of.
Odontogenic tumors, ameloblastoma, keratocystic odontogenic tumor how to cite this article. This led to the who revising its nomenclature, thus, assigning the term keratocystic odontogenic tumor in lieu of odontogenic keratocyst in the head and neck tumors classification of 2005. Keratocystic odontogenic tumor formerly odontogenic keratocysts koct is a unique. The aim of this study was to describe the clinicopathologic features of 177 keratocystic odontogenic tumors kcots diagnosed in a brazilian population. In 2005, the who established a new classification to the former known odontogenic. Decompression of keratocystic odontogenic tumors leading. In these cases, the use of bone resection surgery with a free margin would be. Smoothened gene alterations in keratocystic odontogenic tumors. Keratocystic odontogenic tumor is not the most common of odontogenic cysts but it is an extremely important one for the pathologist to recognize. Odontogenic keratocyst okc has been the subject of great interest since philipsen introduced the term in 1956.
Ppt odontogenic keratocyst powerpoint presentation free. Mar 15, 2012 in addition, we have confirmed that ecm molecules, including perlecan, play an important role in tumor cell proliferation, as well as in the characteristic tissue architectures of such other odontogenic tumors as adenomatoid odontogenic tumor aot and keratocystic odontogenic tumor kcot. Odontogenic keratocysts make up around 19% of jaw cysts. Keratocystic odontogenic tumors kcots of the jaws are a common manifestation of this syndrome. Early dental epithelial transcription factors distinguish. Download fulltext pdf download fulltext pdf read fulltext. Odontogenic keratocyst an overview sciencedirect topics. According to who classification, kcot is defined as a benign neoplasm of odontogenic origin 2.
Jan 01, 20 consequently, it was looked upon more as a locally aggressive, benign, cystic neoplasm, rather than just a cyst, of odontogenic origin. However, it mostly occurs during the second and third decades of life. The majority of patients are in the age ranges of 2029 and 4059 years, 4 but cases ranging from 5 to 80 years have been reported. Nov 10, 2009 the keratocystic odontogenic tumor is a benign developmental tumor with many distinguishing clinical and histologic features.
Dec 01, 20 keratocystic odontogenic tumor kcot is recently considered as one of benign odontogenic tumors due to its unique clinical, histopathological and biological features. Premalatha b r, patil s, rao r s, reddy n p, indu m. Immunohistochemical expression of protein 53, murine. Cell proliferation and apoptosis in kots publication types. The boneinvasive nature of these tumors has been previously associated with the expression of matrix metalloproteinases mmps, which degrade the extracellular matrix. Typically, the categorization of odontogenic cysts is complex and can cause a dilemma equally for specialists as well as pathologists. Calcifying epithelial odontogenic pindborg tumor in a child. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Keratocystic odontogenic tumor kcot, previously known as odontogenic keratocyst, is a benign cystic lesion often manifesting locally in an aggressive fashion and recurring at a high rate. Odontogenic keratocystskeratocystic odontogenic tumours. Keratocystic odontogenic tumor kcot keratocystic odontogenic tumors kcots show a slight predilection for males and are predominantly found in individuals of northern european descent.
Marsupialization of keratocystic odontogenic tumors of the. Surgical treatment and immediate reconstruction of keratocys. Keratocystic odontogenic tumor in the maxillary sinus. Decompression of keratocystic odontogenic tumors leading to. Pdf keratocystic odontogenic tumor a diagnostic dilemma. Kots represent nearly one third of all primary odontogenic tumors, surpassing odontomas and ameloblastomas in frequency. Marsupialization of keratocystic odontogenic tumors of the mandible. Decompression of keratocystic odontogenic tumors leading to increased fibrosis, but without any change in epithelial proliferation. Keratocystic odontogenic tumor a diagnostic dilemma.
The newly acknowledged neoplastic potential and its implications for treatment strategies are also discussed. Even though there are classical clinical features for each of the odontogenic lesions, at times, it may be difficult to arrive at a clinical. Prognostic factors for keratocystic odontogenic tumor. A meloblastomas and keratocystic odontogenic tumors are major aggressive odontogenic tumors in. A free powerpoint ppt presentation displayed as a flash slide show on id. It is more common in the mandible region and in the male sex. Pdf cell proliferation and apoptosis in keratocystic.
The world health organization who has renamed the odontogenic keratocyst the odontogenic keratocystic tumor okt based mostly on the. Keratocystic odontogenic tumor kcot in the jaws arise from the cell rests of dental lamina and are usually seen during the second to fourth decades of life with a slight male predilection. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Ameloblastoma with predilection for the mandible was the most frequent odontogenic tumor 63%, followed by adenomatoid odontogenic tumor aot 7. The adcs of the solid lesions in the ameloblastomas 1. In 2005, the world health organization renamed the lesion previously known as an odontogenic keratocyst as the keratocystic odontogenic. The aim of the study was to characterize the molecular relationship between ameloblastoma and keratocystic odontogenic tumor kcot by means of a genomewide expression analysis. They arise from the proliferation of the epithelial dental lamina in both maxilla and mandible and occur in patients of all ages. Giant keratocystic odontogenic tumor invading bilateral. It is also the most controversial cyst in both terminology and in treatment. Multiple odontogenic keratocyst, surgical management. The term odontogenic keratocyst was first used by philipsen in the year 1956. The authors hypothesized that keratocystic odontogenic tumors. Diagnosing the most common odontogenic cystic and osseous.
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